Researcher Page
Cláudia Daniela Oliveira de Lacerda Nunes Pinho (PhD)
Assistant Researcher (REQUIMTE)
Address: Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal ;

Phone: +351 220 428 67, Fax: +351 226 093 39

Email: cdnunes@ff.up.pt

GABAI Unit Coordination: No


Research Areas:

Membrane Biophysics and Nanotechnology


Keywords:

Drug-membrane interactions; Liposomes; SAXS; WAXS; Drug delivery systems


Topics:

PRESENT RESEARCH INTERESTS

• Inflammation and anti-inflammatory drugs;

• Interaction of drugs with cell membrane mimetic models: location studies , partition on membrane-aqueous interfaces, structural and biophysical modifications;

• Mimetic models of the cell membrane (liposomes, micelles, supported lipid bilayers, monolayers);

• X-ray scattering (SAXS, WAXS and GIXD);

• Morphological characterization of nanostructures using SEM, TEM and AFM;

• Fluorescence techniques: Steady-state and time-resolved quenching, anisotropy;

• Langmuir isotherms, simple or conjugated with Infrared reflection-absorbance spectroscopy;

• Dynamic light scattering and zeta potential;

• Surface functionalization of nanostructures;

• Silica nanotubes, liposomes and lipid nanoparticles as drug delivery systems;

• Drug loading, targeting and release studies.

• Biomedical applications of nanosystems.


Publications:

PUBLICATIONS IN PEER-REVIEWED JOURNALS

44. C. Pereira-Leite, C. Nunes, S.K. Jamal, I.M. Cuccovia, S. Reis. Nonsteroidal Anti-Inflammatory Therapy: A Journey Toward Safety. Medicinal Research Reviews, 2017. (IF 9.135; Q1) [DOI: 10.1002/med.21424]

43. S.M.T. Cavalcanti, C. Nunes*, S.A. Costa Lima, J.L. Soares-Sobrinho, S. Reis. Multiple Lipid Nanoparticles, a New Generation of Lipid Nanoparticles for Drug Delivery Systems: Lamivudine-MLN Experimental Design. Pharmaceutical Research, 2017. (IF 3.210; Q2) [DOI: 10.1007/s11095-017-2136-0]

42. J. A. Loureiro, S. Andrade, A. Duarte, A.R. Neves, J.F. Queiroz, C. Nunes, E. Sevin, L. Fenart, F. Gosselet, M.A.N. Coelho, M.C Pereira. Resveratrol and Grape Extract-Loaded Solid Lipid Nanoparticles for the Treatment of Alzheimer’s disease. Molecules 2017, 22, 277-285. (IF 2.465; Q2) [DOI: 10.3390/molecules22020277]

41. C.L. Seabra, C. Nunes, M. Gomez-Lazaro, M. Correia, J.C. Machado, I.C. Goncalves, C.A. Reis, S. Reis, M.C. Martins. Docosahexaenoic acid loaded lipid nanoparticles with bactericidal activity against Helicobacter pylori. International Journal of Pharmeutics 2017, 519(1-2), 128-137. (IF 3.994; Q1) [DOI: 10.1016/j.ijpharm.2017.01.014]

40. D. Lopes, C. Nunes, P. Fontaine, B. Sarmento, S. Reis. Proof of pore formation and biophysical perturbations through a 2D amoxicillin-lipid membrane interaction approach. BBA-Biomembranes 2017, 1859(5) 803-812. (IF 3.687; Q1) [DOI: 10.1016/j.bbamem.2017.01.031]

39. A.C. Alves, D. Ribeiro, M. Horta, J.L. Lima, C. Nunes*, S. Reis. The daunorubicin interplay with mimetic model membranes of cancer cells: A biophysical interpretation. BBA-Biomembranes 2017, 1859(5), 941-948. (IF 3.687; Q1) [DOI: 10.1016/j.bbamem.2017.01.034]

38. D. Lopes, S. Jakobtorweihen, C. Nunes, B. Sarmento, S. Reis. Shedding light on the puzzle of drug-membrane interactions: Experimental techniques and molecular dynamics simulations. Progress in Lipid Research 2017, 65, 24-44. (IF 11.238; Q1) [DOI: 10.1016/j.plipres.2016.12.001]

37. Rodrigues, F., A.C. Alves, C. Nunes, B. Sarmento, M.H. Amaral, S. Reis, and M.B.P.P. Oliveira, Permeation of topically applied caffeine from a food by-product in cosmetic formulations: Is nanoscale in vitro approach an option? International Journal of Pharmaceutics 2016, 513(1-2), 496-503. (IF 3.994; Q1) [DOI: 10.1016/j.ijpharm.2016.09.059]

36. A.R. Neves, C. Nunes*, H. Amenitsch, S. Reis. Resveratrol Interaction with Lipid Bilayers: A Synchrotron X-ray Scattering Study. Langmuir 2016, 32(48), 12914-12922. (IF 3.993; Q1) [DOI: 10.1021/acs.langmuir.6b03591]

35. A.C. Alves, D. Ribeiro, C. Nunes, S. Reis. Biophysics in cancer: The relevance of drug-membrane interaction studies. BBA-Biomembranes, 2016, 1858, 2231-2244. (IF 3.687; Q1) [DOI:10.1016/j.bbamem.2016.06.025]

34. A.R. Neves, C. Nunes, S. Reis. Resveratrol induces ordered domains formation in biomembranes: Implication for its pleiotropic action. BBA-Biomembranes, 2016, 1858, 12-18. (IF 3.687; Q1) [DOI:10.1016/j.bbamem.2015.10.005]

33. A.R. Neves, C. Nunes, H. Amenitsch, S. Reis. Effects of resveratrol on the structure and fluidity of lipid bilayers: a membrane biophysical study. Soft Matter, 2016, 12, 2118-2126. (IF 3.798; Q1) [DOI: 10.1039/C5SM02905H]

32. A. C. Alves, I. I. Ramos, C. Nunes, L. M. Magalhães, H. Sklenářová, M. A. Segundo, J. L.F.C. Lima and S. Reis. On-line automated evaluation of lipid nanoparticles transdermal permeation using Franz diffusion cell and low-pressure chromatography. Talanta, 2016, 146, 369-374. (IF 3.545; Q1) [DOI:10.1016/j.talanta.2015.08.070]

31. J. Lopes-de-Araujo, A.R. Neves, V. M. Gouveia, C. C. Moura, C. Nunes*, S. Reis. Oxaprozin-Loaded Lipid Nanoparticles towards Overcoming NSAIDs Side-Effects. Pharmaceutical Research, 2016, 33(2), 301-314. (IF 3.210; Q2) [DOI: 10.1007/s11095-015-1788-x]

30. A. R. Neves, C. Nunes and S. Reis. New Insights on the Biophysical Interaction of Resveratrol with Biomembrane Models: Relevance for Its Biological Effects. Journal of Pysical Chemistry B 2015, 119 (35), 11664-72. (IF 3.302; Q2) [DOI: 10.1021/acs.jpcb.5b05419]

29. V. M. Gouveia, S. A. C. Lima, C. Nunes*, S. Reis. Non-Biologic Nanodelivery Therapies for Rheumatoid Arthritis. Journal of Biomedical Nanotechnology 2015, 11(10), 1701-1721. (IF 5.338; Q1) [DOI:10.1166/jbn.2015.2159]

28. M. F. Pinto, C.C. Moura, C. Nunes, M.A. Segundo, S.AC. Lima, S. Reis. A new topical formulation for psoriasis: Development of methotrexate-loaded nanostructured lipid carriers. International Journal of Pharmaceutics 2014, 477(1-2), 519-526. (IF 3.785; Q1) [DOI:10.1016/j.ijpharm.2014.10.067]

27. D. Lopes, C. Nunes, M. C. Martins, B. Sarmento, S. Reis. Eradication of Helicobacter pylori: Past, present and future. Journal of controlled release 2014, 189C, 169-186. (IF 7.261; Q1) [DOI:10.1016/j.jconrel.2014.06.020]

26. M. Pinheiro, S. Pisco, A.S. Silva, C. Nunes, S. Reis. Evaluation of the effect of rifampicin on the biophysical properties of the membranes: significance for therapeutic and side effects. International Journal of Pharmaceutics 2014, 466 (1-2), 190-197. (IF 3.785; Q1) [DOI: 10.1016/j.ijpharm.2014.03.005]

25. C. Pereira-Leite, C. Nunes, S. Reis. Interaction of nonsteroidal anti-inflammatory drugs with membranes: In vitro assessment and relevance for their biological actions. Progress in Lipid Research 2013 52(4), 571-584. (IF 12.963; Q1) [DOI: S0163-7827(13)00048-9 [pii]10.1016/j.plipres.2013.08.003]

24. S.M. Martins, B. Sarmento, C. Nunes, M. Lucio, S. Reis, D.C. Ferreira. Brain targeting effect of camptothecin-loaded solid lipid nanoparticles in rat after intravenous administration. European Journal of Pharmaceutics and Biopharmaceutics 2013, 85 (3), 488-502. (IF 4.245; Q1) [DOI: S0939-6411(13)00290-7 [pii]10.1016/j.ejpb.2013.08.011]

23. M. Pinheiro, C. Pereira-Leite, M. Arede, C. Nunes, J.M. Caio, C. Moiteiro, J.J. Giner-Casares, M. Lucio, G. Brezesinski, L. Camacho, S. Reis. Evaluation of the structure-activity relationship of rifabutin and analogs: a drug-membrane study. Chemphyschem 2013, 14(12), 2808-2816. (IF 3.360; Q1) [DOI: 10.1002/cphc.201300262]

22. V. Vilas-Boas, R. Silva, C. Nunes, S. Reis, L. Ferreira, C. Vieira, F. Carvalho, M.D. Bastos, F. Remiao. Mechanisms of P-gp inhibition and effects on membrane fluidity of a new rifampicin derivative, 1,8-dibenzoyl-rifampicin. Toxicology Letters 2013, 220(3), 259-266. (IF 3.355; Q1) [DOI: S0378-4274(13)00205-1 [pii]10.1016/j.toxlet.2013.05.005]

21. C. Nunes, D. Lopes, M. Pinheiro, C. Pereira-Leite, S. Reis. In Vitro Assessment of NSAIDs-Membrane Interactions: Significance for Pharmacological Actions. Pharmaceutical Research 2013, 30(8), 2097-2107. (IF 3.952; Q1) [DOI: 10.1007/s11095-013-1066-8]

20. M. Pinheiro, C. Nunes, J.M. Caio, C. Moiteiro, M. Lucio, G. Brezesinski, S. Reis. The influence of rifabutin on human and bacterial membrane models: implications for its mechanism of action. Journal of Physical Chemistry B 2013, 117(20), 6187-6193. (IF 3.377; Q2) [DOI: 10.1021/jp403073v]

19. M. Pinheiro, C. Nunes, J.M. Caio, C. Moiteiro, G. Brezesinski, S. Reis. Interactions of N'-acetyl-rifabutin and N'-butanoyl-rifabutin with lipid bilayers: A synchrotron X-ray study. International Journal of Pharmaceutics 2013, 453(2), 560-568. (IF 3.785 ; Q1) [DOI: S0378-5173(13)00527-9 [pii] 10.1016/j.ijpharm.2013.06.018]

18. C. Nunes*, C.T. Sousa, M.P. Proenca, A. Apolinario, J.L.F.C. Lima, S. Reis, J.P. Araujo, M. Lucio. Synchrotron small angle X-ray scattering for the evaluation of the interaction of silica nanotubes with lipid membranes. RSC Advances 2013, 3(26), 10323-10328. (IF 3.708; Q1) [DOI: 10.1039/c3ra22974b]

17. M. Pinheiro, M. Arede, C. Nunes, J.M. Caio, C. Moiteiro, M. Lucio, S. Reis. Differential Interactions of Rifabutin with Human and Bacterial Membranes: Implication for Its Therapeutic and Toxic Effects. Journal of Medicinal Chemistry 2013, 56(2), 417-426. (IF 5.48; Q1) [DOI: 10.1021/Jm301116j]

16. M. Pinheiro, M. Arede, J.J. Giner-Casares, C. Nunes, J.M. Caio, C. Moiteiro, M. Lucio, L. Camacho, S. Reis. Effects of a novel antimycobacterial compound on the biophysical properties of a pulmonary surfactant model membrane. International Journal of Pharmaceutics 2013, 450(1-2), 268-277. (IF 3.785; Q1) [DOI: 10.1016/j.ijpharm.2013.03.062S0378-5173(13)00297-4 [pii]]

15. C. Pereira-Leite, C. Carneiro, J.X. Soares, C. Afonso, C. Nunes*, M. Lucio, S. Reis. Biophysical characterization of the drug-membrane interactions: the case of propranolol and acebutolol. European Journal of Pharmaceutics and Biopharmaceutics 2013, 84(1), 183-191. (IF 4.245 ; Q1) [DOI: 10.1016/j.ejpb.2012.12.005S0939-6411(12)00421-3 [pii]]

14. J.P. Monteiro, A.F. Martins, C. Nunes, C.M. Morais, M. Lucio, S. Reis, T.J. Pinheiro, C.F. Geraldes, P.J. Oliveira, A.S. Jurado. A biophysical approach to menadione membrane interactions: Relevance for menadione-induced mitochondria dysfunction and related deleterious/therapeutic effects. Biochimica Et Biophysica Acta-Biomembranes 2013, 1828(8), 1899-1908. (IF 3.431; Q2) [DOI: 10.1016/j.bbamem.2013.04.006S0005-2736(13)00118-1 [pii]]

13. C. Pereira-Leite, C. Nunes*, J.L.F.C. Lima, S. Reis, M. Lucio. Interaction of Celecoxib with Membranes: The Role of Membrane Biophysics on its Therapeutic and Toxic Effects. Journal of Physical Chemistry B 2012, 116(46), 13608-13617. (IF 3.607; Q2) [DOI: 10.1021/Jp304037v]

12. C. Nunes, C.T. Sousa, M.P. Proenca, D.C. Leitao, J.L.F.C. Lima, S. Reis, J.P. Araujo, M. Lucio. pH sensitive silica nanotubes as rationally designed vehicles for NSAIDs delivery. Colloids and Surfaces B-Biointerfaces 2012, 94, 288-295. (IF 3.554; Q1) [DOI: 10.1016/j.colsurfb.2012.02.003]

11. A.M.S. Cardoso, S. Trabulo, A.L. Cardoso, A. Lorents, C.M. Morais, P. Gomes, C. Nunes, M. Lucio, S. Reis, K. Padari, M. Pooga, M.C.P. de Lima, A.S. Jurado. S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: Implications for cell internalization. Biochimica Et Biophysica Acta-Biomembranes 2012, 1818(3), 877-888. (IF 3.389; Q2) [DOI: 10.1016/j.bbamem.2011.12.022]

10. C. Nunes, G. Brezesinski, C. Pereira-Leite, J.L.F.C. Lima, S. Reis, M. Lucio. NSAIDs Interactions with Membranes: A Biophysical Approach. Langmuir 2011, 27(17), 10847-10858. (IF 4.186; Q1) [DOI: 10.1021/La201600y]

9. C. Nunes, G. Brezesinski, D. Lopes, J.L.F.C. Lima, S. Reis, M. Lucio. Lipid-Drug Interaction: Biophysical Effects of Tolmetin on Membrane Mimetic Systems of Different Dimensionality. Journal of Physical Chemistry B 2011. 115(43), 12615-12623. (IF 3.696; Q1) [DOI: 10.1021/Jp206013z]

8. C. Nunes, G. Brezesinski, J.L.F.C. Lima, S. Reis, M. Lucio. Effects of non-steroidal anti-inflammatory drugs on the structure of lipid bilayers: therapeutical aspects. Soft Matter 2011, 7(6) 3002-3010. (IF 4.39; Q1) [DOI: 10.1039/C0sm00686f]

7. C. Nunes, G. Brezesinski, J.L.F.C. Lima, S. Reis, M. Lucio. Synchrotron SAXS and WAXS Study of the Interactions of NSAIDs with Lipid Membranes. Journal of Physical Chemistry B 2011, 115(24) 8024-8032. (IF 3.696; Q1) [DOI: 10.1021/Jp2025158]

6. L.M. Magalhaes, C. Nunes, M. Lucio, M.A. Segundo, S. Reis, J.L.F.C. Lima. High-throughput microplate assay for the determination of drug partition coefficients. Nature Protocols 2010, 5(11), 1823-1830. (IF 8.362; Q1) [DOI: 10.1038/nprot.2010.137]

5. J. Brittes, M. Lucio, C. Nunes, J.L.F.C. Lima, S. Reis. Effects of resveratrol on membrane biophysical properties: relevance for its pharmacological effects. Chemistry and Physics of Lipids 2010, 163(8), 747-754. (IF 2.861 ; Q2) [DOI: 10.1016/j.chemphyslip.2010.07.004]

4. M. Lucio, C. Nunes, D. Gaspar, K. Golebska, M. Wisniewski, J.L.F.C. Lima, G. Brezesinski, S. Reis. Effect of anti-inflammatory drugs in phosphatidylcholine membranes: A fluorescence and calorimetric study. Chemical Physics Letters 2009, 471(4-6), 300-309. (IF 2.291; Q2) [DOI: 10.1016/j.cplett.2009.02.047]

3. M. Lucio, C. Nunes, D. Gaspar, H. Ferreira, J.L.F.C. Lima, S. Reis. Antioxidant Activity of Vitamin E and Trolox: Understanding of the Factors that Govern Lipid Peroxidation Studies In Vitro. Food Biophysics 2009, 4(4), 312-320. (IF 1.537; Q2) [DOI: 10.1007/s11483-009-9129-4]

2. C. Sousa, C. Nunes, M. Lucio, H. Ferreira, J.L.F.C. Lima, J. Tavares, A. Cordeiro-Da-Silva, S. Reis. Effect of nonsteroidal anti-inflammatory drugs on the cellular membrane fluidity. Journal of Pharmaceutical Sciences 2008, 97(8), 3195-3206. (IF 2.996; Q2) [DOI: 10.1002/Jps.21218]

1. C. Nunes, C. Sousa, H. Ferreira, M. Lucio, J.L.F.C. Lima, J. Tavares, A. Cordeiro-Da-Silva, S. Reis. Substituted phenols as pollutants that affect membrane fluidity. Journal of Environmental Biology 2008, 29(5), 733-738. (IF 1.359; Q3)


Supervision:

PHD STUDENTS

ONGOING

• José Plácido Lopes de Araújo

Unveiling Novel Anticancer Drugs Activity through biophysical studies: Applications in Drug Delivery Systems.

International Doctoral Programme in Molecular and Cellular Biotechnology Applied to Health Sciences (BiotechHealth). ICBAS/FFUP, Portugal.

Grant: PhD program BiotechHealth

Supervisor: Cláudia Nunes

September 2014 – present.

• Daniela Priscila Lopes de Campos

Improvement of the current therapy against Helicobacter pylori: biophysical studies of drug-membrane interaction and development of a dual-drug delivery system.

International Doctoral Programme in Molecular and Cellular Biotechnology Applied to Health Sciences (BiotechHealth). ICBAS/FFUP, Portugal.

Grant: PhD program BiotechHealth

Supervisor: Salette Reis; Co-Supervisors: Cláudia Nunes and Bruno Sarmento

Jan 2013 – present

• Ana Catarina Alves

Design, synthesis and characterization of innovative nanosystems for targeted delivery of anticancer drugs.

Doctoral Program in Pharmaceutical Sciences – Nanotechnologies. FFUP, Portugal.

Grant: SFRH/BD/82443/2011, FCT.

Supervisor: Cláudia Nunes; Co-Supervisor: José Luís Costa Lima

Jan 2012 – present

MSC STUDENTS

CONCLUDED

• Ana Rita Isidoro da Cunha Leal

Paclitaxel loaded hybrid magnetic-lipid nanoparticles as a novel approach for breast cancer therapy. Master Degree in Bioengineering - Molecular Biotechnology. FEUP/ICBAS. University of Porto.

Supervisor: Cláudia Nunes; Co-Supervisor: Salette Reis

Concluded on 21/12/2016.

• Ana Rita Oliveira Macedo Pinto

Amoxicillin-loaded lipid nanoparticles against Helicobacter pylori infections. Master Degree in Bioengineering - Molecular Biotechnology. FEUP/ICBAS. University of Porto.

Supervisor: Salette Reis; Co-Supervisor: Cláudia Nunes

Concluded on 21/07/2016.

• Miguel Diogo de Freitas Horta

Paclitaxel loaded magnetic lipid nanoparticles. ICBAS/ FEUP, Portugal. Integrated Master in Bioengeneering

Supervisor: Cláudia Nunes; Co-Supervisor: Salette Reis

Concluded on 09/10/2015.

• Sarah Sadik Koch Jamal.

The contribution of drug-membrane biophysical studies for the development of safer NSAID: the case of diclofenac. Integrated Masters in Bioengineering Molecular Biotechnology. FEUP/ICBAS. University of Porto.

Supervisor: Salette Reis; Co-Supervisor: Cláudia Nunes

Concluded on 14/07/2015.

• Daniela Filipa Pinto Ribeiro

Assessment of anticancer drugs’ effects on membrane biophysical properties using model membranes. Integrated Master in Bioengineering. FEUP/ICBAS, University of Porto.

Supervisor: Salette Reis; Co-Supervisor: Cláudia Nunes

Concluded on 11/05/2015.

• Suellen Silveira Moraes

Nanofios Multissegmentados, Nanodiscos e Nanopartículas Lipídicas Magnéticas para Aplicações em Medicina. FCUP, Portugal.

Master in Medical Physics

Supervisor: Célia Sousa; Co-Supervisor: Cláudia Nunes

Concluded on 17/10/2014.

• Virgínia Adorinda Moura Gouveia

pH sensitive liposomes for the treatment of rheumatoid arthritis. Master in Biomedical Engineering FFUP.

Supervisor: Cláudia Nunes; Co-Supervisor: Salette Reis

Concluded on 10/10/2014.

• José Plácido Lopes de Araújo.

Oxaprozin-loaded Lipid Nanoparticles towards overcoming NSAIDs side-effects. Integrated Master in Bioengineering. FEUP/ICBAS, University of Porto.

Supervisor: Salette Reis; Co-Supervisor: Cláudia Nunes

Concluded on 10/07/2014.

• Miriam Machado.

Transdermal delivery of pH responsive liposomes containing indomethacin for the treatment of Rheumatoid Arthritis. Integrated Master in Bioengineering. FEUP/ICBAS, University of Porto.

Supervisor: Salette Reis; Co-Supervisor: Cláudia Nunes

Concluded on 10/10/2013

RESEARCH TRAINING

• José Plácido Lopes de Araújo (2012/2013).

Encapsulação de Quantum Dots em Lipossomas: síntese e caracterização.” FEUP/ ICBAS, Portugal. Project II of the Integrated Master in Bioengineering.

Supervisor: Salette Reis; Co-Supervisor: Cláudia Nunes

• Maria Catarina Figueiral da Silva Pereira Leite. (2008/2009).

Collaboration in the orientation of the activities of the project of Research Integration entitled: “Estudos para clarificar o efeito terapêutico e tóxico do Meloxicam: papel da biofísica membranar e das interacções fármaco-membrana”. Msc Pharmaceutical Sciences, FFUP.

• Daniela Priscila Rodrigues Lopes. (2009/2010).

Collaboration in the orientation of the activities of the project of Research Integration entitled: “Avaliação dos efeitos toxicológicos de fármacos sobre uma perspectiva de biofísica membranar”. Msc Pharmaceutical Sciences, FFUP.

SUPERVISION OF FOREIGNER STUDENTS ON MOBILITY PROGRAMS

• Suellen Melo Tibúrcio Cavalcanti. “Desenvolvimento tecnológico de terapias medicamentosas antirretrovirais pediátricas.” 02/03/15 to 01/03/2016.

Universidade Federal de Pernanbuco, Recife.

• Laura Farkuh. “Estudo e Desenvolvimento de Lipossomas de Ácido Láurico para o Tratamento da Acne.” 02/09/2014 to 06/12/2014.

Universidade de São Paulo, Instituto de Química, Departamento de Bioquímica, Laboratório de sistemas biomiméticos.

Bolsa Santander Luso-Brasileira


Projects:

PRINCIPAL RESEARCHER

• Biophysical studies of antimicrobial drugs-membrane Interactions using 2D membrane mimetic models

CALIPSO founded program: Sirius-2 beamline at Soleil Synchrotron (Saint-Aubin, France).

Reference: 20140683.

• Evaluation of antituberculosis drugs on the biophysical properties of the membrane studied 3D model systems.

CALIPSO founded program SAXs bemline at Elettra Sincrotrone (Trieste, Italy).

Reference: 20135320.

EXECUTIVE RESEARCHER

ONGOING

• ACTONP53- Targeting p53 familly proteins: on the route to new anticancer agents.

PTDC/DTP-FTD/1981/2014

• Navigating through marine-derived fungi: bioprospection and synthesis of bioactive secondary metabolites and analogues as chemotherapic agents.

PTDC/MAR-BIO/4694/2014

• PYLORIBINDERS- Helicobacter pylori specific biomaterials for antibiotic-free treatment/diagnostic of gastric infection.

PTDC/CTM-BIO/4043/2014

• Dotar a região Norte de uma unidade de caracterização avançada de membranas – estrutura e mecanismo de transporte.

Norte-07-0162-FEDER-000088

CONCLUDED

• Nanoquímica.

Norte-07-0124-FEDER-000067

• Evaluation of novel nonsteroidal anti-inflammatory drugs on the biophysical properties of the membrane studied 2D model systems.

CALIPSO founded program: Sirius-2 beamline at Soleil Synchrotron (Saint-Aubin, France). Reference: 20130142.

• Biophysical studies of cell penetrating peptides (CPP) on 3D and 2D membrane model systems.

Hamburger Synchrotronstrahlungslabor HASYLAB at Deutsches Elektronen-Synchrotron DESY (Hamburg, Germany). Reference: I-20110271 EC 2011-2012.

• Evaluation of novel antitubercular drugs on the biophysical properties of the membrane studied with 3D and 2D model systems.

Hamburger Synchrotronstrahlungslabor HASYLAB at Deutsches Elektronen-Synchrotron DESY (Hamburg, Germany). Reference: II-20100139 EC 2010-1012.

• Antibody-directed liposomes for Alzheimer`s disease.

PTDC/QUI-BIQ/118076/2010.

• Biophysical characterization of Silica nanotubes - membrane interactions using 3D and 2D model membrane systems.

Hamburger Synchrotronstrahlungslabor HASYLAB at Deutsches Elektronen-Synchrotron DESY (Hamburg, Germany). Reference: I-20090160 EC 2009-2010.

• Interaction of nonsteroidal anti-inflammatory drugs (NSAID) with 3D and 2D model membrane systems.

Hamburger Synchrotronstrahlungslabor HASYLAB at Deutsches Elektronen-Synchrotron DESY (Hamburg, Germany). Reference: I-20080033 EC 2008-2009.

• Development of azacalix(hetero)arene transporters for mediated anionic flux across membranes: a novel approach for studying ionic passive diffusion.

PTDC/QUI-QUI/101022/2008.



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GABAI-Grupo de Análises Bioquímicas, Ambientais e Industriais, 2013

Dept of Chemical Sciences | Faculty of Pharmacy of University of Porto | Rua de Jorge Viterbo de Ferreira, 228, 4050 – 313 Porto, Portugal | Tel. +351 220428500 | Fax. +351 226093483